Quantitative Morphology: Volumes, Shapes and Voxel-Based Measures

Most of the approaches dedicated to automatic morphometry rely on a pointby-point strategy based on warping each brain towards a reference coordinate system. The coordinate system is three dimensional for the comparison of the local densities of grey and white matter (voxel-based morphometry), or two dimensional (spherical) for the comparison of cortical thickness. A more intuitive alternative approach is based on Regions of Interest defined either maually or authomatically. The volumes and shapes of these ROIs (for insatnce sulci and gyri) can be compared across subjects. This talk will give an overview of these different strategies.